Synthesis and Biological Evaluation of some Condensed Thieno [2, 3 D] Pyrimidines for Analgesic and Anti-inflammatory Activity.
Vikram Veer* , Amit Kasabe , Vivek Ingale , Vipul Dhasade
Assistant Professor 1,2,3,4 , 1,2 4 Department of Pharmaceutical Chemistry, Department of Pharmacology PDEA's S.U. College of Pharmaceutical Sci. & Research Centre, Kharadi, Pune‑411014.
Corresponding Author: Mr. Vikram Veer
E-mail: vikramveer05@gmail.com
Submission: 02.07.2020 Acceptance: 17.08.2020 Publication: 31.08.2020
https://www.doi.org/10.63778/PDEASIJRAAS-ARJCPL/2020_0022
Abstract: Pain and inflammation is the most common occurring disorder in human beings and mainly caused by bacterial infections. Though this is most prevalent disorder and many chemotherapeutic, analgesic and anti-inflammatory drugs prescribed many of them have side effects like gastric or intestinal ulceration, increased bleeding time due to inhibition of thromoboxane-A2. Thus there is need to develop agents having more potency at smaller dose and also less side effects. Hence the research work carried out by synthesizing some condensed thieno [2,3 d ] pyrimidine compounds and same compounds were evaluated for an analgesic, anti-inflammatory activity. Amongst the title compounds synthesized, compounds [ IVa-1, IVb-1] having bromine (halogen) as a substituent present on phenyl ring found to be having moderate analgesic and anti-inflammatory activity rather than other synthesized compounds compared with reference standard Diclofenac Sodium.