Employment of Spray Drying As An Impending Particle Engineering Tool For Development of Solid Dispersion of Carvedilol
Sharwaree R. Hardikar , Sunil K. Jena , Ashok V. Bhosale
1 HOD and Associate Professor, 2 P. G. Scholar , 3 Professor and HOD , Department of Pharmaceutics PDEA'S Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune - 412301, Maharashtra, India
Corresponding Author: Dr. Sharwaree R. Hardikar
E-mail: sharwareehardikar@gmail.com
Submission: 23.12.2018 Acceptance: 05.01.2019 Publication:15.02.2019
https://www.doi.org/10.63778/PDEASIJRAAS-ARJCPL/2019_2153
Abstract: Carvedilol (CAR) belongs to Biopharmaceutics Classification System (BCS) class II and hence there is strong need of improvement in its dissolution characteristics. The widely accepted approach to achieve this is the preparation of solid dispersion (SD) of CAR. The objective of the present investigation was to improve the dissolution rate of CAR, through thermodynamically stable solid dispersion. Since instability of physical form of SD is major hurdle in its commercial application: spray drying method was used to prepare SD of CAR. The SDs prepared in various compositions was found to be stable when exposed to 40ºC and 75% relative humidity for 3 months. Physicochemical characterization and dissolution study of SD at the end of stability studies clearly indicated that stability of SD was due to hydrogen bonding between drug and poloxamer 188 and HPMC E-5. This bonding remained unaffected even under stressful conditions of high temperature and humidity. These facts were further supported by significant improvement in dissolution efficiency of SD at t15min as compared to pure drug even at the end of stability studies.